Mortality Effects of Healthy versus Unhealthy Plant Based Diets

In this meta-analysis, researchers review epidemiological studies that employed a simple classification system to assess both how healthy a diet is and how vegan it is, the plant-based diet index. It is perfectly possible to eat an unhealthy vegan diet: just consume a lot of sugar and processed grains. The result is much as one might expect, in that those adhering to a more vegan diet exhibit lower mortality provided that the diet is healthy. There is some debate regarding which of the possible mechanisms are important in producing this outcome, such as levels of inflammation, a modestly lower overall calorie and protein intake, and so forth.

The adherence to plant-based diets has been shown to positively impact longevity by reducing the incidence and severity of lifestyle-related diseases. Previous studies on the association of plant-based dietary pattern, as evaluated by plant-based dietary index (PDI), healthy plant-based dietary index (hPDI) and unhealthy plant-based dietary index (uPDI), with mortality risk have reported inconsistent results. We performed the present meta-analysis to summarize evidence on this association and to quantify the potential dose-response relationship based on all available cohort studies.

A total of 11 eligible cohort studies (13 datasets) were eventually included in this meta-analysis. Participants in the highest quintile of both the PDI and hPDI had a significantly decreased risk of all-cause mortality (pooled hazard ratio for PDI = 0.85; pooled hazard ratio for hPDI = 0.86) compared to participants in the lowest quintile. In contrast, the highest uPDI was associated with an increased risk of mortality (pooled hazard ratio for uPDI = 1.20). In conclusion, greater adherence to PDI or hPDI dietary pattern was associated with a lower risk of mortality, whereas uPDI dietary pattern was positively associated with mortality risk.

Link: https://doi.org/10.3389/fnut.2025.1518519

Comments

A lot of the claims for plant-based diets are nonsense. The critical word in the description is 'healthy'. You can be a really unhealthy vegan or omnivore because you stuff yourself with carb-laden, sugary foods. You can equally be very healthy on pure carnivore or vegan, though in the latter case there is the need to supplement.

Posted by: Neal Asher at February 14th, 2025 1:55 AM

The concluding sentence is offensive and is inconsistent with the enormous data favoring healthy plant based diets for heart disease prevention and reversal, cancer prevention (and now treatment with adjunctive fasting mimicking diets, plant based, pioneered by Valter Longo, PhD), and dementia reversal pioneered by Dean Ornish, MD. To write that "You can equally be very healthy on pure carnivore or vegan, though in the latter case there is the need to supplement" is to sell out to bloggers, TikTok and You Tube and abandon PubMed. Your own organization has published many reviews of papers linking red meat to cancer and the opposite for plant diets. To emphasize that supplements, like inexpensive B12, might enhance an all plant, whole food diet, might be a disadvantage is ludicrous. I would rather my patients take B12 for their whole food plant diet than take chemotherapy for their colorectal or breast cancer associated with animal foods, no matter how grass fed or organic they are.

Posted by: Joel Kahn, MD, FACC at February 15th, 2025 1:41 PM

| papers linking red meat to cancer

B) All the papers in this 'category' I have checked ( ~ 100 ) invariably omit A :D 'detail' factor which in my opinion is the real cause of the cancers. I will however never mention it publicly but only in one-on-one IRL.

( facebook. com / groups / fightaging. org. students. paris )

Posted by: benoît ( paris ) at February 16th, 2025 4:47 PM

comments mention meats causing cancer and so wrong as need full understanding. Yes hotdogs to cause cancer. Have read so many studies on diets. And studies some looking and going back million years ago having populations in north eating mostly big game animals so not factory farmed and less issues. Yes most of these people dead from trauma in 20 so hard to tell fully. But man ate variety of wild organic plants, meats and fish. So this is best - so ok some wild meats and wild fish and then organic veggies. Crazy these vegan extremest and one way view. Eat wild and organic and not ultra processed garbage.

Posted by: Michael at February 16th, 2025 5:38 PM
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