Nectandrin B Extends Life in Flies
Extension of life in short-lived species via manipulation of aspects of metabolism using supplements and small molecules tends to be larger than that in long-lived species. So a 40% extension of life in flies is not as interesting as it would be in mice, for example. Nonetheless, few approaches have been shown to extend life span in flies to this degree. So this may be a strategy that will modestly improve measures of health in humans.
Phytochemicals are increasingly recognized in the field of healthy aging as potential therapeutics against various aging-related diseases. Nutmeg, derived from the Myristica fragrans tree, is an example. Nutmeg has been extensively studied and proven to possess antioxidant properties that protect against aging and alleviate serious diseases such as cancer, heart disease, and liver disease. However, the specific active ingredient in nutmeg responsible for these health benefits has not been identified thus far.
In this study, we present evidence that Nectandrin B (NecB), a bioactive lignan compound isolated from nutmeg, significantly extended the lifespan of the fruit fly Drosophila melanogaster by as much as 42.6% compared to the control group. NecB also improved age-related symptoms including locomotive deterioration, body weight gain, eye degeneration, and neurodegeneration in aging D. melanogaster. This result represents the most substantial improvement in lifespan observed in animal experiments to date, suggesting that NecB may hold promise as a potential therapeutic agent for promoting longevity and addressing age-related degeneration.
Don't run out to consume a lot of nutmeg however. toxicity arising from nutmeg is underreported. do your research.