Towards Clinical Trials for ISRIB
ISRIB has for some years been under investigation as a way to reduce the impact of neurodegeneration and improve cognitive function. It is one of a number of small molecule approaches to upregulate forms of cellular housekeeping, the unfolded protein response in this case. More cellular maintenance in principle means a lower burden of molecular damage and cellular dysfunction at any given time. Since most of these maintenance processes appear to decline in efficacy with age, improvement is a compensatory strategy that might help. In many cases exercise produces more impressive effects than the present state of the art in pharmacology, however. We shall see how ISRIB does in humans, but the mouse data is interesting.
ISRIB has restored memory formation in mice months after traumatic brain injuries and shown potential in treating neurodegenerative diseases, including Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis (ALS). It also seems to reduce age-related cognitive decline. Researchers believe that the reason the molecule can do so much is that it plays an essential role in how the brain handles stress from physical injuries or neurological diseases. Under siege from such problems, the brain, in essence, shuts down cognitive functions like memory formation to protect itself. The new molecule reverses that.
Will ISRIB work to reverse cognitive decline in people? We still don't know. So far most of the work has been done in mice or human cells in a petri dish. But we will soon know more: in 2015 the molecule was licensed by Calico Labs, the Silicon Valley biotech established by the founders of Google to find drugs based on the biology of aging. It aims to transform the molecule into a treatment for a wide array of disorders, including ALS and Parkinson's disease, as well as the damage from traumatic brain injury. In 2021, Calico announced that human safety trials had begun on the first drug candidate for neurodegenerative diseases it had developed based on ISRIB, and that a study in ALS patients was slated to begin later in the year.
hi my mother in bad shape dementia. interested in isrib's.. time is of the essance. thankyou.
Tell Joe Biden to use Operation warp speed and get this drug developed fast and to perfection. And Mix it in a cocktail with the dimentia drug that just came out! If a mouse can be saved than for sure a human! I would pay $8000 for it!
This research seems very promising.
How do I get to be part of the clinical trials for humans? Contact me please.
Hello,
The last I heard Google had taken over the study of this drug from UC San Francisco. It looks like the studies have progressed. Is this true? If so it could be the finding of the century for so many suffering from cognitive decline, Alzheimer's, brain damage, Down's Syndrome and so much more.
Thank you,
Frances
Hype. In studies, didn't work in all mice species. Studies in cultured cells.Murine (mice) chemically or deliberate trauma induced open brain damage. Plz read studies.Tried in dog, but it died from cardiomyopathy. Snake oil.
My wife has been diagnosed with mild/moderate Alzheimer's and we are very interested in the research that ISRIB might restore her short-term memory. Please forward to me any information you might have on how she can participate in this study.
Considering the thousands of veterans who suffer from service-related cognitive disabilities, it is unethical to slow walk this drug development just to hyper-detail its efficacy. "A good plan now is better than a perfect plan later." GEN George S. Patton. We need a "conditional FDA approval for use" that frees up its being given to those with work limiting/constraining disabilities.
My husband was diagnosed with dementia in February of this year. He has been on Donezepril to slow the dementia down.
Really can't tell if it's made any effect. I would love for my husband to be part of this study and get his hands on some of this ISRIB.
Please contact me as soon as more news is available. God bless you and all your work and your endeavors to save human kind from this terrible disease.
Please help my son was born with not enough oxygen to the brain now he is suffering from 30 percent brain Dammage he is also non verbal and autistic he is only 5 years old. I want him to have a prosperous future where he can care for himself. Please help me get the drug
Yomna Ahmad, you can buy it online nut please be careful
Please tell us how the clinical trials are doing? Who do we contact about the trials to be a part of study? My husband is moderate to mild. Tried so many dead end roads. Time is runing out. Id head down to Calif to find this lab and see if hubby can be a part of trial. Thx for a response.
where can find out about up coming clinical trials