A Brief Look at Mitochondria in Aging
A short piece on mitochondria and their role in aging: "Despite propaganda to the contrary, aging is rarely a pleasurable experience. A lifetime of damage to cells and tissues results in malfunction, making old age a significant risk factor for ailments such as cancers and neurologic disabilities typified by Alzheimer's disease. As a consequence, the graying of world populations has triggered a scientific frenzy to unravel the basic processes behind aging and find ways to slow down and perhaps even prevent age-related degeneration. ... Two linked ideas are at the core of our current aging theory. The first is that proteins, RNA and DNA are bombarded with and damaged by reactive oxygen species (ROS) generated during normal cellular respiration and this results in eventual decline and disease. The second is that mitochondria are the major culprits behind aging. ... micro-injection of mitochondria from 'young' cells, those which haven't divided very much, can overcome senescence in cells that are reaching the natural end of their lives and will probably, in the usual course of things, undergo programmed cell death, or apoptosis which is also largely controlled by mitochondria. ... Further support for the 'mitochondrial theory' of aging [comes] from studies in a range of organisms including yeast, nematode worms, flies and mice showing that by silencing certain mitochondrial genes - mitochondria have their own circular genomes - life span is extended."
Link: http://www.decodedscience.com/mitochondria-life-death-and-the-agents-of-aging/2428