An Overview of Metabolism, Damage and Aging

A good, long introduction to the way in which normal metabolic processes push you into aging and disease can be found at DiabetesHealth. Along the way, the article heaps praise on the practice of calorie restriction, which is usually a good way to know the writer has their head screwed on right: "At first glance, human centenarians would appear to have very little in common with calorie-restricted animals. After all, humans can eat what they want when they want, and many centenarians did just that. There is no evidence that centenarians followed a particular diet or even had particularly healthy life styles. Some centenarians smoked, some did not; some exercised regularly, some did not; and some were careful eaters, and some ate whatever they felt like. Despite the obvious differences, there are some striking similarities between caloric-restricted laboratory animals and free-living centenarians. Centenarians and calorie-restricted animals share a particular bio-metabolic profile that distinguishes them from their peers who die younger and sicker. We now know the common denominators that are found in almost all living beings - whether they are worms, mice, monkeys or humans - that defy the odds and live beyond their expected life span."

Link: http://www.diabeteshealth.com/read/2008/01/13/5617.html

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